发明名称 |
TETRACYCLINE-REGULATED ADENO-ASSOCIATED VIRAL (AAV) VECTORS FOR GENE DELIVERY TO THE NERVOUS SYSTEM |
摘要 |
A vector and a method are provided for delivering a nucleic acid to a nervous system cell. The vector includes a first nucleic acid, a second nucleic acid, inverted terminal repeats of adeno-associated virus, and a tetracycline-off regulatable promoter system that includes a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid. The promoters drive expression in opposite directions and away from the inverted terminal repeats. The method includes providing a recombinant adeno-associated viral (rAAV) vector and administering the vector to a nervous system cell. Expression of a product from the first nucleic acid is regulatable by the promoter system. |
申请公布号 |
WO2005116224(A3) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005US15612 |
申请日期 |
2005.05.05 |
申请人 |
CHILDREN'S MEMORIAL HOSPITAL;BOHN, MARTHA, C.;JIANG, LIXIN |
发明人 |
BOHN, MARTHA, C.;JIANG, LIXIN |
分类号 |
A61K48/00;C12N15/86;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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