ASSAYS FOR THE IDENTIFICATION OF MODULATORS OF MHC CLASS II EXPRESSION

摘要

The present invention provides methods for accurate and efficient detection of compositions that specifically modulate the interaction and/or activity of CIITA, RFXANK, RFXAP and RFX5 polypeptide factors. Further methods are provided for identifying compositions whose specific modulation of these transcription factors affects expression of a MHC class II promoter. The disclosed methods are configured in an assay format useful in moderate and high throughput screening applications.