发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO FC GAMMA RECEPTOR I (CD64) |
摘要 |
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to CD64 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating autoimmune disorders, transplant rejection, Graft Versus Host Disease, or cancer and for enhanced presentation of antigen using conjugates of an antigen and an anti-CD64 antibody. |
申请公布号 |
WO2006002438(A3) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005US22991 |
申请日期 |
2005.06.03 |
申请人 |
MEDAREX, INC.;GRAZIANO, ROBERT;SUNDARAPANDIYAN, KARUNA |
发明人 |
GRAZIANO, ROBERT;SUNDARAPANDIYAN, KARUNA |
分类号 |
C07K16/28;A61K39/00;A61K39/395;C12N5/10;C12N5/16;C12N15/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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