IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA

摘要

#CMT# #/CMT# An isolated JAK2 (Janus kinase 2) protein is a mutation of the amino acid 617, and especially mutation V617F, with its sequence present in SEQ ID No. 1, or a similar sequence in other mammals, is new. The nucleotide sequence coding for the variant JAK2 V617F is especially SEQ ID No 2 possessing the t/g mutation in position 1849 from the ATG marking the start of the transcription. #CMT#USE : #/CMT# Diagnosis of myeloproliferative syndromes related to variant JAK2 V617F. #CMT#ADVANTAGE : #/CMT# The identification of the protein allows specific inhibitors to be produced. #CMT#DESCRIPTION OF DRAWINGS : #/CMT# The drawing is a diagram showing the key role of JAK2 in Vaquez-type polyglobulia. (Drawing contains non-English language text).