发明名称 |
TRANSDERMAL DELIVERY SYSTEMS |
摘要 |
Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided. |
申请公布号 |
WO2006047362(A2) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005US38086 |
申请日期 |
2005.10.21 |
申请人 |
DURECT CORPORATION;YUM, SU, II;THEEUWES, FELIX |
发明人 |
YUM, SU, II;THEEUWES, FELIX |
分类号 |
A61K9/70;A61K31/445 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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