NOVEL AMINOPYRIDINE DERIVATIVES HAVING SELECTIVE AURORA-A INHIBITORY EFFECT

摘要

A compound represented by the following general formula [I] or its pharmaceutically acceptable salt or ester, an Aurora-A selective inhibitor or an anticancer agent containing the same, and the combined use of the above anticancer agent with another anticancer agent: [I] wherein m₁ and m₂ represent each 1, 2 or 3; n₁ and n₂ represent each 0 or 1; i is an integer of from 1 to m₁; j is an integer of from 1 to m₂; R represents optionally substituted aryl, heteroaryl or cycloalkyl; R_al and R_al' represent each hydrogen, etc.; R_bj and R_bj' represent each hydrogen, etc.; R_c, R_d and R_e represent each hydrogen, etc.; X₁ represents CH, CX_1a or N; X₂ represents CH, N, etc.; X₃ represents CH, N, etc.; X₄ represents CH, N, etc.; Y₁, Y₂ and Y₃ are the same or different and each represents CH or N; Z₁ and Z₂ are the same or different and each represents CH or N; and W represents a 5-membered aromatic heterocycle such as pyrazole or thiazole.