| 摘要 |
The present invention relates to novel benzo[1,2,5]oxadiazoles and benzo[1,2,5]thiadiazoles of formula (I) wherein X is O or S, R<SUB>1 </SUB>is 5-(2-fluoro-ethylamino)-thiazol-2-yl, 5-(2-<SUP>18</SUP>F-ethylamino)-thiazol-2-yl or a group of formula (a) wherein Y is CH or N, R<SUB>2 </SUB>is NHCH<SUB>3</SUB>, NH<SUP>11</SUP>CH<SUB>3</SUB>, N(CH<SUB>3</SUB>)<SUP>11</SUP>CH<SUB>3</SUB>, N(CH<SUB>3</SUB>)<SUB>2</SUB>, N(<SUP>11</SUP>CH<SUB>3</SUB>)<SUB>2</SUB>, NH(CH<SUB>2</SUB>)<SUB>n</SUB>F, NH(CH<SUB>2</SUB>)<SUB>n</SUB><SUP>18</SUP>F, N(CH<SUB>3</SUB>)(CH<SUB>2</SUB>)<SUB>n</SUB>F, N(CH<SUB>3</SUB>)-(CH<SUB>2</SUB>)<SUB>n </SUB><SUP>18</SUP>F, O-(CH<SUB>2</SUB>)<SUB>n</SUB>F, O-(CH<SUB>2</SUB>)<SUB>n </SUB><SUP>18</SUP>F, CONH(CH<SUB>2</SUB>)nF or CONH(CH<SUB>2</SUB>)<SUB>n</SUB><SUP>18</SUP>F (n being in each case 2 to 4) and R<SUB>3 </SUB>is hydroxy, (C1-4)alkoxy, hydrogen or nitro, in free base or acid addition salt form; their preparation, their use as markers in diagnosis and compositions containing them.
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