3-CARBAMOYL-2-PYRIDONE DERIVATIVE

摘要

A compound represented by the general formula (I): (wherein R<SUP>1</SUP> is optionally substituted C<SUB>1-8</SUB> alkyl, etc.; R<SUP>2</SUP> is C<SUB>1-6</SUB> alkyl and R<SUP>3</SUP> is C<SUB>1-6</SUB> alkyl, etc., provided that R<SUP>2</SUP> and R<SUP>3</SUP> may be bonded to each other to form an optionally substituted 5- to 10-membered nonaromatic carbocycle; R<SUP>4</SUP> is hydrogen, etc.; and G is a group selected among, e.g., groups represented by the formula (X) (wherein R<SUP>5</SUP> is hydrogen, etc.; X<SUP>1</SUP> is a single bond, etc.; X<SUP>2</SUP> is, e.g., optionally substituted C<SUB>1-8</SUB> alkylene optionally having one or two atoms or groups selected between -O- and -N(R<SUP>6</SUP>)- (R<SUP>6</SUP> is hydrogen, etc.); X<SUP>3</SUP> is a single bond, etc.; Y is -O-, etc.; and Z is hydrogen, etc.)), a pharmaceutically acceptable salt of the compound, or a solvate of either. These compounds have cannabinoid receptor agonistic activity. Also provided are a medicinal composition, an atopic dermatitis remedy, and an anti-itching agent, especially an anti-itching agent for oral administration or for external use, which each contains any of those compounds as an active ingredient.