COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF NAV1.8
摘要
<p>The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Na<SUB>v</SUB>1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.</p>
申请公布号
WO2006047687(A2)
申请公布日期
2006.05.04
申请号
WO2005US38792
申请日期
2005.10.26
申请人
SCHERING CORPORATION;CANJI, INC.;GOREGAOKER, SAMEER;PRIESTLEY, TONY;HUNTER, JOHN, C.
发明人
GOREGAOKER, SAMEER;PRIESTLEY, TONY;HUNTER, JOHN, C.