发明名称 |
Drug efflux pump inhibitor |
摘要 |
A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a physiologically acceptable salt thereof, or a hydrate thereof:
wherein R 1 and R 2 independently represent hydrogen atom, a halogen atom, carboxyl group and the like; J 1 represents a 5- or 6-membered heteroaromatic ring; W 1 represents -CH=CH-, -C‰¡C-, -CH 2 CH 2 - and the like; A 1 represents phenylene group, pyridinediyl group, furandiyl group and the like; G 1 represents oxygen atom, carbonyl group, ethynyl group and the like; p represents an integer of from 0 to 3; G 2 represents phenylene group, furandiyl group, tetrahydrofurandiyl group and the like; G 3 represents -CH 2 - or single bond; m and n represent an integer of 0 or 1; and Q 1 represents an acidic group.
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申请公布号 |
EP1652839(A2) |
申请公布日期 |
2006.05.03 |
申请号 |
EP20050019514 |
申请日期 |
2000.10.27 |
申请人 |
DAIICHI PHARMACEUTICAL CO., LTD.;TRINE PHARMACEUTICALS, INC. |
发明人 |
LEGER, ROGER;WATKINS, WILLIAM JOHN;ZHANG, JASON ZHIJIA;RENAU, THOMAS ERIC;LEE, VING JACK;OHTA, TOSHIHARU;NAKAYAMA, KIYOSHI;ISHIDA, YOHHEI;OHTSUKA, MASAMI;KAWATO, HARUKO |
分类号 |
C07D213/30;A61K31/341;A61K31/41;A61K31/421;A61K31/423;A61K31/425;A61K31/426;A61K31/427;A61K31/433;A61K31/437;A61K31/4375;A61K31/44;A61K31/4439;A61K31/47;A61K31/4709;A61K31/4738;A61K31/502;A61K31/517;A61K31/519;A61K31/5383;A61P31/04;C07D215/14;C07D215/56;C07D263/56;C07D277/26;C07D277/28;C07D277/32;C07D277/44;C07D307/52;C07D513/04;C12Q1/18;G01N33/68 |
主分类号 |
C07D213/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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