| 摘要 |
The present invention is related to an antibody component that binds with the HLA-DR-complex for use in a method for inducing humoral and cellular immune responses in a mammal against a tumor that expresses a tumor associated antigen (TAA) or against a disease caused by an infectious agent, said method comprising:
(a) administering a first vaccine intradermally to the mammal, wherein said first vaccine comprises an immunoconjugate that comprises:
(i) the antibody component that binds with the HLA-DR-complex, and
(ii) an antigenic peptide, wherein said antigenic peptide comprises at least one epitope of a TAA or an antigen associated with said infectious agent,
and
(b) administering said vaccine intravenously to said mammal. |
