摘要 |
The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R<SUP>1</SUP>=-H, -NH<SUB>2</SUB>, -Br, -Cl, -OH, -COOH, B=-N-, -CH-, Z=-CH-, -N-, A=-N- at B=-N-, Z=-CH-, A=-CH- at B=-N-, Z=-CH-, A=-CH- at B=-N-, Z=-N-, A=-CH- at B=-CH-, Z=-CH-, A=-CH- at B=-CH-, Z=-N-, and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base. |