| 摘要 |
1,179,588. Halogen- or trifluoromethylcontaining aryl thiosemicarbazides. CIBA Ltd. 7 Aug., 1967 [11 Aug., 1966; 23 June, 1967], No. 36089/67. Heading C2C. Novel compounds of the Formula (I):- in which Ar represents a phenyl group containing at least one CF 3 group or at least two halogen atoms, Hy represents a hydrazo group, and R 1 and R 2 each represents a hydrogen atom or an organic residue, or, when taken together, a bivalent organic residue, and salts thereof, are obtained by reacting together compounds of the formula Ar-HyH and in which Z represents a chlorothiocarbonyl group, or, when taken together with Z 1 , a thiocarbonyl group, or a salt thereof. N<SP>1</SP> - Ethyl - N - (3,5 - bis - trifluoromethyl. phenyl)-hydrazine is obtained by reacting 3,5- bis - trifluoromethyl - phenylhydrazine, acetic anhydride and triethylamine to form N-(3,5-bistrifluoromethylphenyl)- N<SP>1</SP> - acetylhydrazine, then reducing the latter with LiAlH 4 to form the above product. 5 - Chloro - 3 - trifluoromethyl - phenylhydrazine is obtained by diazotizing 5- chloro-3-trifluoromethylaniline then reducing the diazonium salt with SnCl 2 and HCl. Pharmaceutical compositions, useful as birth control agents, anti-oestrogens and as antiphlogistics, comprise a compound of Formula (I) above together with a pharmaceutical carrier, in forms suitable for enteral or parenteral administration. The compounds may also be used in veterinary medicine as well as in animal feedstuffs and feed additives. |
