发明名称 |
Process for the production of optically active amino alcohols |
摘要 |
An object of the present invention is to provide a process for the production of an optically active amino alcohol, particularly an optically active amino alcohol of a trans-form, being excellent in economy and efficiency, and suitable for industry using easily available and less expensive materials. The present invention relates to a process for the production of an optically active amino alcohol comprising the steps that an optically active hydroxy ester in a trans-form obtained by an asymmetric hydrogenation of an easily available beta-keto ester is reacted with hydrazine, the resulting optically active hydrazinocarbonyl alcohol is subjected to a Curtius rearrangement in the presence of alcohol and protective group of amino group of the resulting optically active alkoxycarbonylamino alcohol is deprotected. As a result of the process for the production in accordance with the present invention, the objected substance is able to be prepared in a high optical purity and in a high yield.
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申请公布号 |
US7038087(B2) |
申请公布日期 |
2006.05.02 |
申请号 |
US20030656617 |
申请日期 |
2003.09.04 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
FUJIWARA TAKAHIRO;NARA HIDEKI;SOTOGUCHI TSUKASA |
分类号 |
C07C209/16;C07B53/00;C07B61/00;C07C67/31;C07C69/757;C07C209/46;C07C209/56;C07C213/02;C07C215/44;C07C269/00;C07C271/24 |
主分类号 |
C07C209/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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