NOVEL MANUFACTURING METHOD OF [2R -(2R*, 3S*, 4R*, 5R*, 8R*, 10R*, 11R*, 12S*, 13S*, 14R*)]-13 -[(2, 6- DIDEOXY 3-C-METHYL -3 -O-METHYL -(-L-RIBO -HEXOPYRANOSYL) OXY]-2-ETHYL-3, 4, 10- TRIHYDROXY -3, 5, 6, 8, 10, 12, 14-HEPTAMETHYL -11-[[3, 4, 6-TRID

摘要

Provided herein is a novel manufacturing process of the anhydrous crystalline form of the [2R -(2R*, 3S*, 4R*, 5R*, 8R*, 10R*, 11R*, 12S*, 13S*, 14R*)]-13 -[(2, 6-Dideoxy -3-C-methyI -3 -O-methyl - (-L-ribo -hexopyranosyl)oxy] -2-ethyl-3, 4, 10- trihydroxy -3, 5, 6, 8, 10, 12, 14-heptamethyl -11-[[3, 4, 6-trideoxy -3-(dimethylamino) -('-D-xyl -5-hexopyranosyl] oxy]-1-oxa-6 -aza cyclopentadecan -15-one compound, which is also known as IUPAC 9- deoxo-9a -aza-9a -methyl-9a- homoerythromycin A obtained from the 9- deoxo-9a -aza-9a- homoerythromycin amine, which is also known as 11-aza-10-deoxo-10duhydroerythromicin.