Substituted tricyclic himbacine derivatives that are useful as thrombin receptor antagonists

摘要

Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salts thereof, wherein: n₁ and n₂ are independently 0-2; Het is an optionally substituted mono-, bi- or tricyclic heteroaromatic group; B is alkyl or optionally substituted alkenyl; R²² is -COR²³ or a carboxy, sulfinyl, sulfonyl, sulfonamide or amino acid derivative; R²³ is haloalkyl; alkenyl; haloalkenyl; alkynyl; optionally substituted cycloalkyl; cycloalkyl-alkyl; aryl; arylalkyl; heteroaryl; heterocycloalkyl; or -COOH and/or -SO₃H substituted alkyl; R¹, R², R³, R⁹, R¹⁰ and R¹¹ are as defined in the specification; are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds.