发明名称 |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
摘要 |
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
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申请公布号 |
US7037890(B2) |
申请公布日期 |
2006.05.02 |
申请号 |
US20010972772 |
申请日期 |
2001.10.05 |
申请人 |
PRAECIS PHARMACEUTICALS, INC. |
发明人 |
OLSON GARY L.;SELF CHRISTOPHER;LEE LILY;COOK CHARLES MICHAEL;BIRKTOFT JENS |
分类号 |
A61K31/336;A61K38/00;A61K38/08;C07D303/32;C07K5/02;C07K5/06;C07K5/083;C07K5/09;C07K5/103;C07K7/06;C07K14/81 |
主分类号 |
A61K31/336 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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