| 摘要 |
THE INVENTION RELATES TO COMPOUNDS OF THE FORMULAWHEREIN@R IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, HALOGEN OR TRIFLUOROMETHYL;@R1 IS HYDROGEN OR HALOGEN; OR@R AND R1 MAY BE BE TOGETHER -CH=CH-CH=CH-;@R2 IS HYDROGEN, HALOGEN, TRIFLUOROMETHYL, LOWER ALKOXY OR CYANO;@R3 IS HYDROGEN, LOWER ALKYL OR FORM A CYCLOALKYL GROUP;@R4IS HYDROGEN, -N(R5)2, -N(R5)S(O)2-LOWER ALKYL, -N(R5)C(O)R5 OR A CYCLIC TERTIARY AMINE OF THE GROUPR5IS, INDEPENDENTLY FROM EACH OTHER, HYDROGEN, C3-6CYCLOALKYL, BENZYL OR LOWER ALKYL;@R6 IS HYDROGEN, HYDROXY, LOWER ALKYL, -N(R5)CO-LOWER ALKYL, HYDROXY-LOWER ALKYL, CYANO, -CHO OR A 5-OR 6 MEMBERED HETEROCYCLIC GROUP, OPTINALLY BONDED VIA AN ALKYLENE GROUP,@X IS -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R5)C(O)-, OR -N(R5)(CH2)m-;@nIS 0-4; AND@mIS 1 OR 2;@AND TO PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THREOF.@IT HAS BEEN SHOWN THAT THE ABOVE MENTIONED COMPOUNDS HAVE A GOOD AFFINITY TO THE NK-1 RECEPTOR.
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