| 摘要 |
THE USE OF A COMPOUND COMPRISING FORMULA (1):OR A SALT, ESTER, AMIDE OR PRODRUG THEREOF IN THE INHIBITION OF AN ENZYME WHOSE PREFERRED MODE OF ACTION IS TO CATALYST THE HYDROLYSIS OF AN ESTER FUNCTIONALLY, E.G. IN THE CONTROL AND INHIBITION OF UNWANTED ENZYMES IN PRODUCTS AND PROCESSES. THE COMPOUNDS ARE ALSO USEFUL IN MEDICINE E.G. IN THE TREATMENT OF OBESITY AND RELATED CONDITIONS. THE INVENTION ALSO RELATES TO NOVEL COMPOUNDS WITHIN FORMULA (1), TO PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.IN FORMULA (1) A IS A 6-MEMBERED AROMATIC OR HETEROAROMATIC RING; AND R1 IS A BRANCHED OR UNBRANCHED ALKYL (OPTIONALLY INTERRUPTED BY ONE OR MORE OXYGEN ATOMS), ALKENYL, ALKYNYL, CYCLOALKYL, CYCLOALKENYL, ARYL, ARYLALKYL, REDUCED ARYLALKYL, REDUCED ARYLALKYL, ARYLALKENYL, HETEROARYL, HETEROARYLALKYL, HETEROARYLALKENYL, REDUCED ARYL, REDUCED HETEROARYL, REDUCED HETEROARYLALKYL OR A SUBSTITUTED DERIVATIVE OF ANY THE FOREGOING GROUPS. |
