发明名称 |
Method of producing Ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate |
摘要 |
A method of producing Ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate by means of liquid chromatography using a packing material comprising a carrier and, carried thereon, a polysaccharide derivative, wherein a part or all of the hydrogen atoms of hydroxyl and amino groups of the polysaccharide derivative are substituted with one or more substituents, such as a carbamoyl group wherein one hydrogen atom is substituted with an aromatic group having a specific alkyl group. The method allows the production of the above (3R,5S,6E) isomer with enhanced productivity to a conventional method.
|
申请公布号 |
US2006089381(A1) |
申请公布日期 |
2006.04.27 |
申请号 |
US20050254864 |
申请日期 |
2005.10.21 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
ONISHI ATSUSHI;TACHIBANA KOZO |
分类号 |
C07D215/14;A61K31/47;C08B37/00 |
主分类号 |
C07D215/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|