摘要 |
<p>1,239,959. Octapeptides. E. R. SQUIBB & SONS Inc. 16 July, 1968 [31 July, 1967], No. 33871/68. Heading C2C. Novel compounds (I) R - Met - ,Gly - Try - Met- Asp - Phe - NH 2 or salts thereof where R is H - Tyr - Asp- or H - Asp - Tyrare prepared by reaction of an active form of H - Asp - Tyr - Met- Gly - OH with H - Try - Met - Asp - Phe - NH 2 or by reaction of H - Gly - Try - Met - Asp- Phe - NH 2 (1) with L - methionine, then L- aspartic acid, and finally L - tyrosine or (2) with L - methionine, then L - tyrosine and finally L- aspartic acid. Intermediates isolated are described and claimed in Specification 1,239,960.</p> |