The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting a2-macroglobulin (a2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of a2-MG, HA and TIMP-1.
申请公布号
WO2005039397(A3)
申请公布日期
2006.04.27
申请号
WO2004US35766
申请日期
2004.10.25
申请人
PROMETHEUS LABORATORIES INC.;OH, ESTHER, H.;SMITH, CATHERINE, M.