PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ALPHA-SUBSTITUTED CARBOXYLIC ACIDS OR ALPHA-SUBSTITUTED CARBOXYLIC ACID AMIDES FROM ENANTIOMERIC MIXTURES OF ALPHA-SUBSTITUTED CARBOXYLIC ACID AMIDES EMPLOYING PSEUDOMONAS FLUORESCENS

摘要

There is provided a process for the preparation of an optically active carboxylic acid or an optically active carboxylic acid amide wherein a carboxylic acid amide having an alpha-carbon substituted with a heteroatom group is enantioselectively hydrolysed in the presence of an enzyme obtainable from Pseudomonas fluorescens to give an optically active carboxylic acid or an optically active carboxylic acid amide. The carboxylic acid amide is preferably a carboxylic acid amide of formula (1): wherein R