发明名称 |
Pregelatinized starch in a controlled release formulation |
摘要 |
The present invention concerns the use of pregelatinized starch to prevent dose-dumping from a hydrophilic controlled release formulation. It also concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release matrix formulation, and solid dosage forms prepared therefrom, preferably for once daily oral administration. The hydrophilic controlled release formulation comprises pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Preferred hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose. |
申请公布号 |
EP1649851(A2) |
申请公布日期 |
2006.04.26 |
申请号 |
EP20050112414 |
申请日期 |
2000.03.24 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
VANDECRUYS, ROGER, PETRUS, GEREBERN;JANS, EUGENE, MARIE, JOZEF |
分类号 |
A61K9/20;A61K47/36;A61K9/16;A61K9/22;A61K9/28;A61K31/445;A61K31/4468;A61K31/505;A61K31/519;A61K47/30;A61K47/38;A61K47/48;C08K5/00;C08L1/04;C08L3/02;C08L101/14 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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