发明名称 |
Anti-VEGF antibodies |
摘要 |
Humanized and variant anti-VEGF antibodies and various uses therefore are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro, and inhabit tumor growth in vivo.
|
申请公布号 |
EP1650220(A2) |
申请公布日期 |
2006.04.26 |
申请号 |
EP20060075078 |
申请日期 |
1998.04.03 |
申请人 |
GENENTECH, INC. |
发明人 |
BACA, MANUEL;WELLS, JAMES A.;PRESTA, LEONARD G.;LOWMAN, HENRY B.;CHEN, YVONNE MAN-YEE |
分类号 |
C07K16/22;C12N15/09;A61K38/00;A61K38/17;A61K39/395;A61P25/00;A61P27/02;A61P35/00;C07K16/46;C12N5/10;C12N15/13;C12N15/63;C12N15/66;C12N15/70;C12P21/02 |
主分类号 |
C07K16/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|