Oral dosage form comprising a liquid active agent formulation and controlling release thereof by an expandable osmotic composition

摘要

The present invention provides a controlled release oral dosage form for the delivery of a liquid active agent formulation. The dosage form of the present invention includes a reservoir formed of a water impermeable material and filled with a liquid active agent formulation. The dosage form of the present invention also includes an expandable osmotic composition positioned within the reservoir, and, optionally, the expandable osmotic composition is separated from contact with the liquid active agent formulation by a barrier layer that is substantially impermeable to the passage of liquid. To facilitate expulsion of the liquid active agent formulation, the dosage form of the present invention also includes an exit orifice. The material make-up and design of the reservoir included in the dosage form of the present invention allow the manufacture of an oral dosage form capable of more consistently achieving a desired release rate or release rate profile of active agent from a liquid formulation.