发明名称 |
USE OF MHC CLASS II LIGANDS AS ADJUVANT FOR VACCINATION AND OF LAG-3 IN CANCER TREATMENT |
摘要 |
The present invention concerns a use of a MHC class II ligand, such as CD4 and LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune response, as well as the use of LAG-3 in cancer-immunotherapy. The invention also concerns a pharmaceutical composition comprising an effective amount of an antigen able to induce an antigen-specific immune response together with an effective amount of MHC class II ligand wherein said MHC class II ligand is present as an adjuvant-like agent. |
申请公布号 |
EP1002108(B1) |
申请公布日期 |
2006.04.26 |
申请号 |
EP19980945090 |
申请日期 |
1998.07.23 |
申请人 |
INSTITUT GUSTAVE ROUSSY;APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
TRIEBEL, FREDERIQUE |
分类号 |
A61K48/00;C12N15/63;A61K38/00;A61K38/17;A61K39/00;A61K39/39;A61M36/14;A61P31/04;A61P31/12;A61P33/10;A61P35/00;A61P37/02;C12N5/08;C12N5/10 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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