Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2

摘要

The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.