FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS
摘要
<p>Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.</p>
申请公布号
EP1438281(A4)
申请公布日期
2006.04.26
申请号
EP20020797056
申请日期
2002.10.28
申请人
OXIGENE, INC.;BAYLOR UNIVERSITY
发明人
CHAPLIN, DAVID J.;GARNER, CHARLES, MANLY, III;KANE, ROBERT, RONALD;PINNEY, KEVIN, G.;PREZIOSO, JOSEPH ANTHONY;EDVARDSEN, KLAUS