| 摘要 |
FIELD: organic chemistry, medicine, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to derivatives of imidazole of the formula (I): or its pharmaceutically acceptable salt. Also, invention relates to a pharmaceutical composition possessing inhibitory activity with respect to prenyl transferase activity, to methods for treatment based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof in aims for treatment of such diseases as fibrosis, prostate benign hyperplasia, atherosclerosis, restenosis, breast cancer, large intestine cancer, pancreas cancer, prostate cancer, lung cancer, ovary cancer, epidermis cancer and hemopoietic organs cancer. ^ EFFECT: valuable medicinal properties of compound and pharmaceutical composition. ^ 18 cl, 1 tbl |
