METHOD FOR BROMINATION OF alpha- AND beta-ERGOCRYPTINES

摘要

FIELD: chemical-pharmaceutical industry, chemical technology. ^ SUBSTANCE: invention relates to a method for preparing neurohormonal agent - abergin (alpha- and beta-bromoergocryptines). Bromination of mixture of alpha- and beta-ergocryptines is carried out with 50% excess of N-bromosuccinimide in chloroform medium with addition of dioxane (10:1). Method involves using dioxane with peroxide content in the amount 0.011-0.0145 mole part with respect to amount of alkaloids in the reaction medium wherein the parent concentration of ergotoxine alkaloids is 0.125-0.150 mole/l. Method provides enhancing yield of the end substance at the key stage of the bromination reaction. ^ EFFECT: improved preparing method. ^ 1 tbl, 2 dwg, 1 ex