发明名称 |
MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES |
摘要 |
The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter "TARGETS") and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerat ive and/or inflammatory diseases such as rheumatoid arthritis. |
申请公布号 |
WO2006040357(A2) |
申请公布日期 |
2006.04.20 |
申请号 |
WO2005EP55315 |
申请日期 |
2005.10.17 |
申请人 |
GALAPAGOS N.V.;KLAASSEN, HUBERTUS, JOHANUS, MATHEUS;BRYS, REGINALD;VANDEGHINSTE, NICK;TOMME, PETER, HERWIG, MARIA |
发明人 |
BRYS, REGINALD;VANDEGHINSTE, NICK;TOMME, PETER, HERWIG, MARIA |
分类号 |
C12N9/12;A61K48/00;C07K14/705;C12N9/02;C12N15/113;G01N33/53 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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