PREVENTION OR IMPROVEMENT OF WRINKLES BY USING ADAM ACTIVATION INHIBITOR

摘要

An agent for preventing or improving wrinkles which comprises a substance inhibiting the activity of ADAM (a disintegrin and metalloprotease) contained in the skin. Wrinkles are prevented or improved by applying the substance, which inhibits the activity of ADAM contained in the skin, to the skin. An anti-wrinkle effect of a test substance is evaluated by using as an indication the enzymatic activity of ADAM or a gene expression level thereof in the skin, a tissue or a cell.