发明名称 |
Modulation of replicative fitness by using less frequently used synonymous codons |
摘要 |
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed. |
申请公布号 |
AU2005294129(A1) |
申请公布日期 |
2006.04.20 |
申请号 |
AU20050294129 |
申请日期 |
2005.10.07 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESNETED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION |
发明人 |
CARA C. BURNS;RAYMOND CAMPAGNOLI;OLEN M. KEW;JING SHAW;JACQUELINE QUAY |
分类号 |
C12N5/10 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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