COMPARTMENTALISED COMBINATORIAL CHEMISTRY BY MICROFLUIDIC CONTROL
摘要
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluid.ic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
申请公布号
WO2006040554(A1)
申请公布日期
2006.04.20
申请号
WO2005GB03927
申请日期
2005.10.12
申请人
MEDICAL RESEARCH COUNCIL;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;GRIFFITHS, ANDREW;WEITZ, DAVID;LINK, DARREN;AHN, KEUNHO;BIBETTE, JEROME