| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for easily, quickly and efficiently removing impurities such as nucleic acids, iron and proteins in a glycosaminoglycan fraction and a method for producing a large amount of glycosaminoglycan fraction free from the impurities. SOLUTION: The method for removing one or more substances selected from nucleic acids, iron and proteins in a glycosaminoglycan fraction contains (1) a step to contact a solution of the glycosaminoglycan fraction with activated carbon and (2) a step to separate the activated carbon contacted with the solution of the glycosaminoglycan fraction and collect the glycosaminoglycan fraction. The invention further provides a method containing the steps (1) and (2) and producing a glycosaminoglycan fraction having the following properties (a) to (c). (a) The content of nucleic acid is <0.08μg per 1 mg of the glycosaminoglycan fraction, (b) the iron content is≤0.07 ppm and (c) the protein content is≤0.4%. COPYRIGHT: (C)2006,JPO&NCIPI
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