| 发明名称 |
High affinity TGFbeta nucleic acid ligands and inhibitors |
| 摘要 |
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFbeta 2. Included in the invention are specific RNA ligands to TGFbeta 2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGFbeta 2 with its receptor.
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| 申请公布号 |
US2006084797(A1) |
申请公布日期 |
2006.04.20 |
| 申请号 |
US20050286221 |
申请日期 |
2005.11.23 |
| 申请人 |
GILEAD SCIENCES, INC. |
发明人 |
PAGRATIS NIKOS;LOCHRIE MICHAEL;GOLD LARRY |
| 分类号 |
C07H21/02;A61K9/127;A61K38/00;A61K47/48;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07K14/00;C07K14/49;C07K14/495;C07K14/50;C12N15/10;C12N15/113;C12N15/115;C12Q1/37;C12Q1/68;C12Q1/70;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76 |
主分类号 |
C07H21/02 |
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