6-AMINO(AZA)INDANE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECPTOR

摘要

The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R^a and wherein Ar may also carry I or 2 radicals R^b; X is N or CH; E is CR⁶R⁷ or NR ³; R¹ is C₁-C₄-alkyl, C₃-C4-cycloalkyl, C₃-C₄-cycloalkylmethyl, C₃-C₄-alkenyl, fluorinated C₁-C₄-alkyl, fluorinated C₃-C₄-cycloalkyl, fluorinated C₃-C₄-cycloalkylmethyl, fluorinated C₃-C₄-alkenyl, formyl or C₁-C₃-alkylcarbonyl; R^1a is H or R^1a and R² or R^1a and R^2a together are (CH₂)_n with n being 1, 2, 3 or 4; R² and R^2a each independently are H, CH₃, CH₂F, CHF₂ or CF₃; R³ is H or C,-C4-alkyl; and the physiologically tolerated acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising at least one compound of the formula (I) or a pharmaceutically acceptable salt thereof and to a method for treating a medical disorder susceptible to treatment with a dopamine D3 receptor ligand, said method comprising administering an effective amount of at least one compound of the formula (I) or a pharmaceutically acceptable salt thereof.