The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using Tethering to identify inhibitors preferentially targeting the inactive conformation.
申请公布号
WO2005034840(A8)
申请公布日期
2006.04.20
申请号
WO2003US29870
申请日期
2003.09.17
申请人
SUNESIS PHARMACEUTICALS, INC.;MORROW, JOELLE;PRESCOTT, JOHN, C.