Method for modification of y-secretase activity through inhibition of Fkbp13

摘要

The present invention provides a method for modifying gamma-secretase activity in a cell or in an organism by de-stabilizing presenilin through inhibition of Fkbp13. Inhibition of Fkbp13 de-stabilizes presenilin and prevents formation of a functional gamma-secretase complex thus decreasing gamma-secretase activity and concomitantly decreasing production of amyloid-beta peptides. The invention also provides methods for identifying agents which function to inhibit Fkbp13.