| 摘要 |
The present invention relates to a process for the preparation of furopyrroles of the general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A 1 and A2 are Cl-C18alkyl, C2- Cl8alkenyl, C2-Cl8alkynyl, C5-C8cycloalkyl, C5- C8cycloalkenyl, aryl or heteroaryl, A3 is hydrogen, C1-C18alkyl, cyanomethyl, Ar3 ,-CR30R31-(CH2)m-Ar3 or Y- R32 , wherein R 30and R31 independently of each other stand for hydrogen or C1-C4alkyl, or phenyl which can be substituted up to three times with C1-C4alkyl, Ar3 stands for aryl, C5-C8 cloalkyl, C5-C8 cycloalkenyl or heteroaryl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, halogen or phenyl, which can be substituted with C1-C8alkyI or C1-C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, R is C1-C18alkyl, in particular C1- C4alkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, which can be substituted one to three times with C1-C 8alkyl, C1-C8alkoxy, or halogen, Y is -C(O)-, -C(O) O-, -C(O)NH-, -SO2NH- or -SO2- and R32 is C 1-Cl8alkyl, Ar3, or aralkyl. The furopyrroles of the general formula (I) can be obtained in high yield and high purity by the process of the present invention.
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