IN SITU DILUTION OF EXTERNAL CONTROLS FOR USE IN MICROARRAYS
摘要
An array in which an external control feature for normalization has been designed and tested for its ability to mimic the range of observed expression levels for a test set of oligos. The external control probes span a series of concentrations. They ar e spatially randomized across a grid of an array. The series of concentrations is duplicated in a given grid. The individual grid layout and number of control and external normalization features per grid have been designed to cope with sources of both systematic error and spatial variation.
申请公布号
CA2485055(A1)
申请公布日期
2006.04.18
申请号
CA20042485055
申请日期
2004.10.18
申请人
HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF
发明人
BOUCHER, SHERRI;PARFETT, CRAIG;YAUK, CAROLE;WILLIAMS, ANDREW;DOUGLAS, GEORGE R.