发明名称 |
LPS-response gene compositions and methods |
摘要 |
The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation are provided; as are methods screening for drugs that may stimulate TNF production. Finally methods of incorporating and expressing the mutant TLR-4 genes into a host cell are contemplated.
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申请公布号 |
US7029861(B1) |
申请公布日期 |
2006.04.18 |
申请号 |
US19990396985 |
申请日期 |
1999.09.15 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BEUTLER BRUCE A.;POLTORAK ALEXANDER |
分类号 |
G01N33/50;C07H21/04;C07K14/00;C12N5/00;C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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