SINGLE CHAIN ANTIGEN-BINDING POLYPEPTIDES FOR POLYMER CONJUGATION.

摘要

The present invention relates to monovalent and multivalent single- -chain antigen-binding polypeptides with site-specific modifications. The provided polypeptides are capable of being covalently linked or conjugated to polyalkylene oxides at the modified sites. The resulting conjugates retain antigen binding properties and exhibit prolonged circulating time and reduced antigenicity relative to unconjugated single chain antigen binding polypeptides. Methods and compositions for making and using the single chain antigen-binding polypeptides with site-specific modifications are also provided.