INDANYLAMINO URACILS AND THEIR USE AS ANTIOXIDANTS AND NEUROPROTECTANTS

摘要

Disclosed are compounds having the structure (Formula I) wherein, R₁ is H, NH₂, NH-(C₁-C₄) alkyl, or N-[(C₁-C₄ )alkyl]₂; R₂ and R₃ are each independently H, (C₁-C₄) alkyl, or structure (Formula II), wherein R₄ is H, (C₁-C₄) alkyl, halogen, hydroxy, (C₁-C₁₀)alkoxy, cyano, nitro, -NR₅R₆, or -OCONR₇R₈; wherein R₅ and R₆ are each independently H, or a substituted or unsubstituted (C₁-C₄) alkyl; and wherein R₇ and R₈ are each independently H, or substituted or unsubstituted (C₁-C₄) alkyl or (C₁-C₁₀)aryl; and wherein only one of R₂ and R₃ is H, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds, pharmaceutical compositions containing such compounds or salts, and processes for their preparation. The subject invention also provides methods of alleviating symptoms of neurologic and inflammatory disorders, methods of preventing oxidation of lipids, proteins, or deoxyribonucleic acids on a cellular level, and methods of protecting human red blood cells from lysis by O₂ radicals.