CHONDROITIN SULFATE A BINDING DOMAINS

摘要

The invention is related to the identification of CSA binding domains in var2CSA homologs from different parasite strains and furthermore to an isolated polypeptide comprising a CSA-binding domain sequence substantially as shown in SEQ ID NO:1, or functional equivalent thereof, or the corresponding portion of PfEMP1 from a strain of Plasmodium, substantially in isolation from sequences naturally occurring adjacent thereto in the PfEMP1 protein, and related nucleotide sequences, vectors, host cells, vaccines, and methods of use.