The present invention is a solid dosage form for oral administration of ibuprofen comprising a modified release formulation of ibuprofen which provides an immediate burst effect and thereafter a sustained release of sufficient ibuprofen to maintain blood levels at least 6.4 µg/ml over an extended period of at least 8 hours following administration of a single dose. The dosage form releases ibuprofen at a rate sufficient to initially deliver a effective amount of ibuprofen within about 2.0 hours following administration. The dosage form then subsequently delivers the remaining amount of ibuprofen at a relatively constant rate sufficient to maintain a level of ibuprofen over a predetermined delivery period of for at least 8 hours.
申请公布号
WO2006039692(A2)
申请公布日期
2006.04.13
申请号
WO2005US35630
申请日期
2005.09.30
申请人
SCOLR PHARMA, INC.;HITE, MICHAEL;FEDERICI, CATHY;BRUNELLE, ALAN;TURNER, STEPHEN
发明人
HITE, MICHAEL;FEDERICI, CATHY;BRUNELLE, ALAN;TURNER, STEPHEN