A PROCESS FOR PREPARATION OF 2-N-BUTYL -4-CHLORO - 1 - {[2`- (2-TRIPHENYLMETHYL - 2H - TETRAZOLE - 5- YL) - 1, 1' - BIPHENYL-4-YL] METHYL}-LH- IMIDAZOIE-5-METHANOL (INTERMEDIATE OF LOSARTAN)
摘要
<p>The present invention relates to a process for preparation of N-substituted heterocyclic derivative,2-n-Butyl-4-chloro- 1 - { [2' -(2-triphenylmethyl-2H-tetrazole-5-yl)- 1,1' -biphenyl -4-yl] methyl} -lH-imidazole-5-methanol, an important intermediate in the synthesis of Losartan and its pharmaceutically acceptable salts using phase transfer catalyst and minimal number of solvents with improved yield.</p>
