SINGLE AMINO ACID MUTATION PROTEIN OF HISTONE H3, ITS MUTANT CELL AND THEIR USE

摘要

PROBLEM TO BE SOLVED: To provide a novel yeast cell line given a new characteristics by introducing single amino acid mutation into histone H3 or H4 without directly engineering a gene encoded by a genome DNA and its transcription product, and its use.

SOLUTION: Disclosed are a mutant yeast cell expressing a mutant histone H3 protein or histone H4 protein in which a specific amino acid residue is substituted by alanine residue, those mutant histone proteins, polynucleotides encoding these mutant proteins, and a method for using these cells, proteins and polynucleotides.

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