发明名称 |
MODULATION OF SURVIVIN EXPRESSION |
摘要 |
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, blunt-ended siRNAs and single-stranded antisense RNA compounds. Methods of using these compounds for modulation of survivin expression and for treatment of diseases associated with expression of survivin are provided. |
申请公布号 |
WO2005002507(A3) |
申请公布日期 |
2006.04.13 |
申请号 |
WO2004US17490 |
申请日期 |
2004.06.03 |
申请人 |
ISIS PHARMACEUTICALS, INC.;ELI LILLY AND COMPANY;BHAT, BALKRISHEN;PATET, BHARVIN, KUMAR;SWAYZE, ERIC |
发明人 |
BHAT, BALKRISHEN;PATET, BHARVIN, KUMAR;SWAYZE, ERIC |
分类号 |
C07H21/04;A61K;A61K48/00;C12N15/00;C12N15/113 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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